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Der Nuklearmediziner 2008; 31(1): 8-11
DOI: 10.1055/s-2008-1004624
PET und Strahlentherapie

© Georg Thieme Verlag Stuttgart · New York

PET in der Strahlentherapie: Perspektiven

PET in Radiation Oncology - PerspectivesM. Baumann1 , 3 , B. Beuthien-Baumann2 , 3 , 4 , D. Zips1 , 3
  • 1Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Medizinische Fakultät, Universitätsklinikum Carl Gustav Carus, TU Dresden
  • 2Klinik und Poliklinik für Nuklearmedizin, Medizinische Fakultät, Universitätsklinikum Carl Gustav Carus, TU Dresden
  • 3OncoRay - Zentrum für Innovationskompetenz Strahlenforschung in der Onkologie, Medizinische Fakultät, Universitätsklinikum Carl Gustav Carus, TU Dresden.
  • 4PET-Zentrum, Forschungszentrum Dresden-Rossendorf
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Publication History

Publication Date:
28 February 2008 (online)

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Zusammenfassung

Die Positronen-Emissions-Tomografie (PET) hat einen wichtigen Stellenwert in der modernen Strahlentherapie erlangt. Die Integration der funktionellen PET-Daten in die Bestrahlungsplanung wurde durch die Fusion von CT und PET in einem Gerät wesentlich erleichtert. Entwicklungs- und Optimierungsbedarf besteht jedoch in der Definition der Tumorgrenzen im PET und im Umgang mit Atembewegungen. Neben dem am häufigsten zur Anwendung kommenden Radiopharmakon 18F-Fluordesoxyglukose (FDG) sind die Anwendung von Hypoxiemarkern und Radiotracerentwicklungen für die Visualisierung anderer definierter radiobiologischer Resistenzmechanismen wünschenswert.

Abstract

Positron emission tomography (PET) has evolved as an important tool in modern radiotherapy. Integration of functional PET data into radiation treatment planning is facilitated due to PET-CT scanner, optimizing data fusion. Optimization of definition of tumour borders and reduction of movement artifacts is warranted. Besides the application of 18F-fluorodeoxyglucose (FDG) utilization of tracers visualizing hypoxia and the development of novel tracers depicting other defined biological mechanisms of radioresistance is a promising avenue for future research.

Schlüsselwörter

PET / CT - FDG - Bestrahlungsplanung - Strahlenbiologie - Hypoxie - Theragnostics

Key words

PET / CT - FDG - radiation treatment planning - radiation biology - hypoxia - theragnostics

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Dr. B. Beuthien-Baumann

Klinik und Poliklinik für Nuklearmedizin · Universitätsklinikum

Fetscherstr. 74

01307 Dresden

Phone: +49 / 3 51 / 2 60 27 55

Email: b.beuthien@fzd.de