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Int J Sports Med 1986; 07(6): 338-341
DOI: 10.1055/s-2008-1025788
© Georg Thieme Verlag Stuttgart · New York

Jogging Causes a Significant Increase in Platelet Sensitivity to Prostacyclin*

H. Sinzinger, P. Fitscha
  • Atherosclerosis Research Group (ASF) at the Department of Medical Physiology, University of Vienna, Atherosclerosis and Thrombosis Research Group (ATK) of the Austrian Academy of Sciences and 2nd Department of Internal Medicine, Policlinic, Vienna, Austria
* This study was supported by a grant of the “Fonds zur Förderung der wissenschaftlichen Forschung” Projekt Nr. 40.
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Publikationsdatum:
14. März 2008 (online)

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Abstract

Platelet function and platelet sensitivity to PGI2 was studied before and after Jogging in seven males and four females in good health. The ADP-induced (1 µM) aggregation, being always increased after physical activity, showed during the entire follow-up period of 12 months a significant decrease at rest and after exercise compared with baseline values. The change in the aggregation response was significant for tα at month 1 and for Δtmax at month 2 after starting the jogging.

The platelet sensitivity to PGI2, being always diminished after exercise, also increased significantly during the entire follow-up period compared with baseline levels. In contrast to the ADP-induced changes, the changes in platelet sensitivity were significant already at week 2. Our findings indicate that daily physical activity causes a significant improvement in platelet function and reduces platelet activation.

Key words

jogging - platelet sensitivity - prostacyclin - ADP-induced platelet aggregation