An Efficient, One-Pot Synthesis of S-Alkyl Thiocarbamates from the Corresponding Thiols Using the Mitsunobu Reagent

Devdutt Chaturvedi; Nisha Mishra; Virendra Mishra

doi:10.1055/s-2008-1032025

SHORTPAPER

An Efficient, One-Pot Synthesis of S-Alkyl Thiocarbamates from the Corresponding Thiols Using the Mitsunobu Reagent

Devdutt Chaturvedi*^a, Nisha Mishra^b, Virendra Mishra^b
^a Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India
e-Mail: ddchaturvedi002@yahoo.co.in;
^b Synthetic Research Lab, Department of Chemistry, B. S. A. P. G. College, Mathura 281 004, India

Abstract

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Abstract

A novel Mitsunobu-based protocol has been developed for the synthesis of variety of S-alkyl thiocarbamates from the corresponding thiols and amines using gaseous carbon dioxide, in good to excellent yields. This protocol is mild and efficient compared to other reported methods.

Key words

thiols - carbon dioxide - Mitsunobu reagent - thiocarbamates

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