Synthesis of Deuterium-Labeled Azo Dyes of the Sudan Family

Abstract

Carcinogenic amines are formed in vivo during the metabolism of Sudan azo dyes. The identification and assay of these polluting agents requires the availability of deuterated analogues. Accordingly, two series of derivatives labeled on the phenylazo and naphthol moieties were synthesized. The new compounds were obtained in satisfactory chemical yields and with an excellent degree of labeling. The structures were confirmed by ¹H NMR spectroscopy and high-resolution mass spectrometry.

Key words

labeled azo dyes - labeled amines - azo compounds - coupling - deuterium labeling

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