DBU/Et₃N-Mediated Sequential Homoaldol-Lactonization-Alkylation Reactions of Ethyl Pyruvate: One-Pot Synthesis of O-Protected Isotetronic Acids

Abstract

The sequential homoaldol-lactonization-alkylation/acylation­ reactions of ethyl pyruvate with a variety of halides were achieved by using DBU along with Et₃N as the base. The protocol provides an expedient one-pot synthesis of O-protected isotetronic acid derivatives. The high-yielding synthesis of an unprotected isotetronic acid is also described.

Key words

pyruvate - aldol reactions - one-pot reactions - isotetronic acids

References

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