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Synthesis 2008(5): 725-728
DOI: 10.1055/s-2008-1032168
DOI: 10.1055/s-2008-1032168
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Highly Functionalized Pyrrole Derivatives via a Four-Component Reaction of Two Primary Amines and Diketene in the Presence of Nitrostyrene
Weitere Informationen
Received
7 November 2007
Publikationsdatum:
08. Februar 2008 (online)
Publikationsverlauf
Publikationsdatum:
08. Februar 2008 (online)
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Abstract
The one-pot synthesis of highly functionalized pyrrole derivatives from the reaction of an enaminone, which can be derived from the reaction between two primary amines and diketene, in the presence of nitrostyrene is described. The reaction occurred under neutral conditions and in excellent yields.
Key words
amine - diketene - enaminones - nitrostyrene - pyrrole - multicomponent reaction
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