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DOI: 10.1055/s-2008-1034300
© Georg Thieme Verlag KG Stuttgart · New York
Antimycobacterial Substances from Phaeosphaeria sp BCC8292
Publication History
Received: August 10, 2007
Revised: January 7, 2008
Accepted: January 10, 2008
Publication Date:
27 February 2008 (online)
![](https://www.thieme-connect.de/media/plantamedica/200803/lookinside/thumbnails/10.1055-s-2008-1034300-1.jpg)
Abstract
Eleven substances including naphthalenones, naphthoquinones, unsymmetrical naphthoquinone dimers and a chlorinated diphenyl ether, three of which are new, have been isolated from the fungus Phaeosphaeria sp. The absolute stereochemistry of naphthalenones has been determined by the Mosher and exciton chirality methods. The biological activity of these compounds against Mycobacterium tuberculosis and cytotoxicity against KB, BCA, NCI-H 187 and Vero cell lines were evaluated.
Key words
Antimycobacterial - Phaeosphaeria - wood-decaying fungus - Poaceae - naphthalenone - naphthoquinone - naphthoquinone dimer
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Dr. Pattama Pittayakhajonwut
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