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DOI: 10.1055/s-2008-1034309
© Georg Thieme Verlag KG Stuttgart · New York
A Norsesquiterpene Lactone and a Benzoic Acid Derivative from the Leaves of Cyclocarya paliurus and their Glucosidase and Glycogen Phosphorylase Inhibiting Activities
Publikationsverlauf
Received: October 30, 2007
Revised: January 7, 2008
Accepted: January 14, 2008
Publikationsdatum:
26. Februar 2008 (online)
![](https://www.thieme-connect.de/media/plantamedica/200803/lookinside/thumbnails/10.1055-s-2008-1034309-1.jpg)
Abstract
Two novel compounds, 3-methoxypterolactone (1) and 2-amino-3,4-dihydroxy-5-methoxybenzoic acid (2), were isolated from leaves of Cyclocarya paliurus (Batal.) Iljinsk, together with nine known compounds: pterolactone (3), gallic acid (4), 4-hydroxy-3-methoxybenzoic acid (5), oleanolic acid (6), β-boswellic acid (7), α-boswellic acid (8), β-amyrin (9), β-amyrone (10) and 3β-O-trans-caffeoyl-morolic acid (11). The structure elucidation was based on spectroscopic methods, including two-dimensional NMR experiments (1H-1H COSY, HMQC and HMBC). All isolated compounds were evaluated for their glycosidase and glycogen phosphorylase inhibitory activities. 2-Amino-3,4-dihydroxy-5-methoxybenzoic acid and gallic acid showed significant α-glucosidase and glycogen phosphorylase inhibitory activities.
Key words
Cyclocarya paliurus - Cyclocaryaceae - 3-methoxypterolactone - 2-amino-3,4-dihydroxy-5-methoxybenzoic acid - α-glucosidase - glycogen phosphorylase
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Prof. Dr. Yongcheng Lin
Dr. Zhigang She
School of Chemistry and Chemical Engineering
Sun Yat-sen University
Guangzhou 510275
People’s Republic of China
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