Planta Med 2008; 74(4): 427-431
DOI: 10.1055/s-2008-1034345
Natural Products Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Diarylheptanoids from the Rhizomes of Alpinia officinarum

Yi Sun1 , Keiichi Tabata1 , Hideki Matsubara1 , Susumu Kitanaka1 , Takashi Suzuki1 , Ken Yasukawa1
  • 1College of Pharmacy, Nihon University, Chiba, Japan
Further Information

Publication History

Received: September 26, 2007 Revised: February 4, 2008

Accepted: February 6, 2008

Publication Date:
26 March 2008 (online)

Abstract

Bioassay-guided fractionation of the cytotoxic MeOH extract from the rhizomes of Alpinia officinarum Hance led to the isolation of two new diarylheptanoids named alpinoid D (1) and E (2), together with fifteen known diarylheptanoids (3 - 17). The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic data and chemical evidence. The cytotoxic activity of the isolated diarylheptanoids was evaluated against the IMR-32 human neuroblastoma cell line. Among the tested compounds, 11, 12 and 14 exhibited the most potent activities with IC50 values of 0.83, 0.23 and 0.11 μM, respectively.

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Prof. Dr. Ken Yasukawa

College of Pharmacy

Nihon University

7-7-1, Narashinodai

Funabashi-shi

Chiba 274-8555

Japan

Phone: +81-47-465-1107

Fax: +81-47-465-1107

Email: self-med@pha.nihon-u.ac.jp