Thorac Cardiovasc Surg 2008; 56(6): 359-362
DOI: 10.1055/s-2008-1038671
Original Thoracic

© Georg Thieme Verlag KG Stuttgart · New York

Effects of Hyperbaric Oxygen Therapy on Wound Healing After Tracheal Resection and End-to-End Anastomoses in Rats: Results of Early Observations

R. Gorur1 , A. Hahoglu2 , G. Uzun3 , A. Kutlu4 , H. Turut1 , N. Yiyit1 , F. Candas1 , T. Isitmangil1
  • 1Department of Thoracic Surgery, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey
  • 2Department of Pathology, GATA Haydarpasha Teaching Hospital, Istanbul, Turkey
  • 3Department of Hyperbaric and Undersea Medicine, GATA Haydarpasha Teaching Hospital, Istanbul, Turkey
  • 4Department of Chest Disease, GATA Haydarpasha Teaching Hospital, Istanbul, Turkey
Further Information

Publication History

received January 30, 2008

Publication Date:
14 August 2008 (online)

Abstract

Background: Proliferating scar tissue is an important problem after tracheal surgery. Hyperbaric oxygen (HBO) provides good support to the poorly perfused tissues. We aimed to evaluate the early effects of HBO therapy on tracheal healing after tracheal resection. Methods: A total of 15 Wistar rats were divided into two groups and two tracheal rings of each rat were resected. A control group received no therapy while the other group was treated with HBO. At the end of the study or when a rat died, a histopathological examination was performed to assess neovascularization, necrosis and epithelization. Results: HBO treatment caused better epithelization and inflammation scores compared to the control group. In the HBO group the intraluminal purulent exudates were limited (p = 0.001). Healing of the damaged mucosal epithelium was better in the HBO group (p = 0.031). In the HBO-treated group, neovascularization also started earlier than in the group without HBO. Conclusion: Our short-term observation results demonstrate that HBO treatment increases tracheal healing and decreases the complication ratios. HBO may be preferred as a supportive treatment modality during the healing period after tracheal surgery.

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Dr. Rauf Gorur

GATA Haydarpasa Teaching Hospital
Department of Thoracic Surgery

Acibadem Cad.

34660 Istanbul

Turkey

Fax: + 90 21 63 25 72 57

Email: araufg@yahoo.com