Abstract
The effect of 30 days of β-alanine supplementation (4.8 g per day) on resistance exercise performance and endocrine changes was examined in eight experienced resistance-trained men. An acute resistance exercise protocol consisting of 6 sets of 12 repetitions of the squat exercise at 70 % of one-repetition maximum (1-RM) with 1.5 minutes of rest between sets was performed before and after each supplemental period. Blood draws occurred at baseline (BL), immediate (IP), 15-minutes (15P) and 30-minutes (30P) postexercise for growth hormone, testosterone and cortisol concentrations. A 22 % (p < 0.05) difference in total number of repetitions performed at the end of 4 weeks of supplementation was seen between β-alanine (BA) and placebo (PL), and Δ mean power was greater in BA (98.4 ± 43.8 w) vs. PL (7.2 ± 29.6 w). Growth hormone concentrations were elevated from BL at IP and 15P for both groups, while cortisol concentrations were greater than BL at all time points for both BA and PL. No group differences were noted. No change from BL was seen in testosterone concentrations for either group. Results indicate that four weeks of β-alanine supplementation can significantly improve muscular endurance during resistance training in experienced resistance-trained athletes. However, these performance gains did not affect the acute endocrine response to the exercise stimulus.
Key words
endocrine - erogenic aid - strength - athletic performance
References
-
1
Asatoor A M, Bardon J K, Lant A F, Milne M D, Navab F.
Intestinal absorbtion of carnosine and its constituent amino acids in man.
Gut.
1970;
11
250-254
-
2
Derave W, Özdemir M S, Harris R C, Pottier A, Reyngoudt H, Koppo K, Wise J A, Achten E.
Beta-alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters.
J Appl Physiol.
2007;
103
1736-1743
-
3
Dill D B, Costill D L.
Calculation of percentage changes in volume of blood, plasma and red cells in dehydration.
J Appl Physiol.
1974;
37
247-248
-
4
Dunnett M, Harris R C.
Influence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus medius.
Equine Vet J Suppl.
1999;
30
499-504
-
5
Gordon S E, Kraemer W J, Vos N H, Lynch J M, Knuttgen H G.
Effect of acid-base balance on the growth hormone response to acute high-intensity cycle exercise.
J Appl Physiol.
1994;
76
821-829
-
6
Hakkinen K, Pakarinen A.
Acute hormonal responses to two different fatiguing heavy-resistance protocols in male athletes.
J Appl Physiol.
1993;
74
882-887
-
7
Harris R C, Tallon M J, Dunnett M, Boobis L, Coakley J, Kim H J, Fallowfield J L, Hill C A, Sale C, Wise J A.
The absorption of orally supplied β-alanine and its effect on muscle carnosine synthesis in human vastus lateralis.
Amino Acids.
2006;
30
279-289
-
8
Hill C A, Harris R C, Kim H J, Harris B D, Sale C, Boobis L H, Kim C K, Wise J A.
Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity.
Amino Acids.
2007;
32
225-233
-
9 Hoffman J R. Norms for Fitness, Performance, and Health. Champaign, IL; Human Kinetics 2006: 27-39
-
10
Hoffman J R, Im J, Rundell K W, Kang J, Nioka S, Speiring B A, Kime R, Chance B.
Influence of muscle oxygenation during resistance exercise on the anabolic hormonal response.
Med Sci Sports Exerc.
2003;
35
1929-1934
-
11
Hoffman J R, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J R.
Effect of creatine and β-alanine supplementation on performance and endocrine responses in strength/power athletes.
Int J Sport Nutr Exerc Metab.
2006;
16
430-446
-
12
Horinishi H, Grillo M, Margolis F L.
Purification and characterization of carnosine synthetase from mouse olfactory bulbs.
J Neurochem.
1978;
31
909-919
-
13
Kraemer W J, Gordon S E, Fleck S J, Marchitelli L J, Mello R, Dziados J E, Friedl K, Harman E, Maresh C, Fry A C.
Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females.
Int J Sports Med.
1991;
12
228-235
-
14
Kraemer W J, Marchitelli L J, Gordon S E, Harman E A, Dziados J E, Mello R, Frykman P N, McCurry D, Fleck S J.
Hormonal and growth factor responses to heavy-resistance exercise protocols.
J Appl Physiol.
1990;
69
1442-1450
-
15
Kraemer W J, Ratamess N A, Volek J S, Häkkinen K, Rubin M R, French D N, Gómez A L, McGuigan M R, Scheett T P, Newton R U, Spiering B A, Izquierdo M, Dioguardi F S.
The effects of amino acid supplementation on hormonal responses to resistance training overreaching.
Metab Clin Exper.
2006;
55
282-291
-
16
Mannion A F, Jakeman P M, Dunnett M, Harris R C, Willan P L.
Carnosine and anserine concentrations in the quadriceps femoris muscle in healthy humans.
Eur J Appl Physiol Occup Physiol.
1992;
64
47-50
-
17
Parkhouse W S, McKenzie D C, Hochachka P W, Ovalle W K.
Buffering capacity of deproteinized human vastus lateralis muscle.
J Appl Physiol.
1985;
58
14-17
-
18
Perry T L, Hansen S, Tischler B, Bunting R, Berry K.
Carnosinemia: a new metabolic disorder associated with neurologic disease and mental defect.
N Eng J Med.
1967;
277
1219-1226
-
19
Ratamess N A, Hoffman J R, Ross R, Shanklin M, Faigenbaum A D, Kang J.
Effects of an amino acid/creatine/energy supplement on performance and the acute hormonal response to resistance exercise.
Int J Sport Nutr Exerc Metab.
2007;
17
608-623
-
20
Stout J R, Cramer J T, Mielke M, O'Kroy J, Torok D J, Zoeller R F.
Effect of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold.
J Strength Cond Res.
2006;
20
928-931
-
21
Stout J R, Cramer J T, Zoeller R F, Torok D, Costa P, Hoffman J R, Harris R C, O'Kroy J.
Effects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.
Amino Acids.
2007;
32
381-386
-
22
Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K.
High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting.
Jap J Phys.
2002;
52
199-205
-
23
Suzuki Y, Ito O, Takahashi H, Takamatsu K.
The effect of sprint training on skeletal muscle carnosine in humans.
Int J Sport Health Sc.
2004;
2
105-110
-
24
Tallon M J, Harris R C, Boobis L H, Fallowfield J L, Wise J A.
The carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders.
J Strength Cond Res.
2005;
19
725-729
Dr. Jay Hoffman
The College of New Jersey
Health and Exercise Science
2000 Pennington Rd
Ewing, New Jersey 08628
United States
Phone: +1 60 97 71 30 34
Fax: + 1 60 96 37 51 53
Email: hoffmanj@TCNJ.edu
