Wirkung des 3-Monats-Depot Leuprorelinacetat (Trenantone®) beim prämenopausalen Mammakarzinom – Ergebnisse einer Anwendungsbeobachtung

Zusammenfassung

Fragestellung: Untersuchung von Wirksamkeit und Verträglichkeit einer Ovarialablation mit Trenantone® bei prämenopausalen Patientinnen mit hormonabhängigem Mammakarzinom. Material und Methodik: 133 Dokumentationen zur adjuvanten Behandlung wurden über einen Behandlungszeitraum von 6 Monaten im Rahmen einer Anwendungsbeobachtung bei niedergelassenen Gynäkologen gesammelt. Ergebnisse: Die mittleren Östradiolspiegel lagen nach drei Monaten Behandlung bei 18,1 pg/ml und nach 6 Monaten bei 17,4 pg/ml. Die Amenorrhörate lag nach 6 Monaten Therapie bei 93 %. Insgesamt zeigte sich über den Zeitraum der Behandlung tendenziell eine Verbesserung der Lebensqualität der betroffenen Frauen. Schlussfolgerung: Die Behandlung des hormonabhängigen Mammakarzinoms mit dem 3-Monats-Depot von Leuprorelinacetat führt zu einer adäquaten Downregulation der Östradiolwerte bei guter Verträglichkeit.

Abstract

Purpose: Aim of the following analysis was to evaluate the efficacy and tolerability of ovarian downregulation with Trenantone® in pre-menopausal patients with hormone-sensitive breast cancer. Material and Methods: Data of 133 patients given adjuvant therapy of breast cancer with Trenantone by their gynaecologists over a period of 6 months were collected (post-marketing surveillance study). Results: Median blood levels of oestradiol were 18.1 pg/ml after a treatment period of three months and 17.4 pg/ml after 6 months. Rate of amenorrhoea was 93 % after 6 months. There was a tendency towards an improvement of quality of life in all patients during the time of treatment. Conclusion: Treatment of hormone-sensitive breast cancer with leuprorelin in the form of a 3-month depot injection leads to an adequate decrease in oestradiol levels over time and is a well tolerated therapy.

Schlüsselwörter

Therapie - hormonsensitives Mammakarzinom - prämenopausale Frauen - Leuprorelin 3‐Monats‐Depot - Verträglichkeit - effektive Downregulation

Key words

therapy - hormone sensitive breast cancer - premenopausal women - Leuprorelin 3 month depot - tolerability - efficacy

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