Long-Term Survival of a Patient with Type A Thymoma and Masaoka's Stage IV b: Case Report

Abstract

Thymoma is the most common neoplasm in the anterior mediastinum. This report presents an extremely rare case of a type A thymoma with Masaoka's stage IV b due to lymph node metastasis. In 1997, a 59-year-old man underwent complete resection of a stage IV b type A thymoma with postoperative radiotherapy to the mediastinum. In 2006, small nodules were detected in the anterior mediastinum and above the right diaphragm and tumor resection was performed. The two lesions were both histologically diagnosed as recurrences of the type A thymoma. There has been no evidence of recurrence 15 months after the second surgery.

Key words

Thoracic surgery - mediastinal tumor - thymoma - Masaoka's stage IV b - WHO type A

References

• 1 Rosai J, Sobin L H. Histological Typing of Tumors of the Thymus. International histological classification of tumors. 2nd edition. New York, Berlin; Springer 1999
• 2 Masaoka A, Monden Y, Nakahara K, Tanioka T. Follow-up study of thymomas with special reference to their clinical stages.  Cancer. 1981;  48 2485-2492
• 3 Park M S, Chung K Y, Kim K D, Yang W I, Chung J H, Kim Y S, Chang J, Kim J H, Kim S K, Kim S K. Prognosis of thymic epithelial tumors according to the new World Health Organization histologic classification.  Ann Thorac Surg. 2004;  78 992-997
• 4 Nakagawa K, Asamura H, Matsuno Y, Suzuki K, Kondo H, Maeshima A, Miyaoka E, Tsuchiya R. Thymoma: a clinicopathologic study based on the new World Health Organization classification.  J Thorac Cardiovasc Surg. 2003;  126 1134-1140
• 5 Detterbeck F C. Clinical value of the WHO classification system of thymoma.  Ann Thorac Surg. 2006;  81 2328-2334
• 6 Rieker R J, Hoegel J, Morresi-Hauf A, Hofmann W, Blaeker H, Penzel R, Otto H F. Histologic classification of thymic epithelial tumors: comparison of established classification schemes.  Int J Cancer. 2002;  98 900-906
• 7 Wright C D, Wain J C, Wong D R, Donahue D M, Gaissert H A, Grillo H C, Mathisen D J. Predictors of recurrence in thymic tumors: importance of invasion, World Health Organization histology, and size.  J Thorac Cardiovasc Surg. 2005;  130 1413-1421
• 8 Kondo K, Monden Y. Therapy for thymic epithelial tumors: a clinical study of 1320 patients from Japan.  Ann Thorac Surg. 2003;  76 878-884
• 9 Okumura M, Shiono H, Inoue M, Tanaka H, Yoon H E, Nakagawa K, Matsumura A, Ohta M, Iuchi K, Matsuda H. Outcome of surgical treatment for recurrent thymic epithelial tumors with reference to World Health Organization histologic classification system.  J Surg Oncol. 2007;  95 40-44