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Thorac Cardiovasc Surg 2009; 57(1): 1-6
DOI: 10.1055/s-2008-1039060
Review

© Georg Thieme Verlag KG Stuttgart · New York

Neutrophil Apoptosis by Fas/FasL: Harmful or Advantageous in Cardiac Surgery?

P. Kunes1 , 2 , J. Krejsek2 , M. Brtko1 , J. Mandak1 , M. Kolackova2 , M. Trojackova Kudlova2 , C. Andrys2
  • 1Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic
  • 2Department of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
Further Information

Publication History

received June 19, 2008

Publication Date:
23 January 2009 (online)

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Abstract

Polymorphonuclear leukocytes or neutrophils are the main executors of cellular death, both in septic inflammation during bacterial infection and in sterile inflammation during trauma or surgery. Whereas in septic inflammation neutrophils perform a useful function to fortify the host's defense against infection, in sterile inflammation, by contrast, they contribute to unwelcome tissue damage. Regardless of the situation, activated neutrophils exhibit a prolonged lifespan and delayed apoptotic death which, under normal conditions, is a prerequisite for their natural renewal. Traditionally, delayed neutrophil apoptosis was considered to promote trauma or surgical injury. According to the results of recent studies, however surprising they may appear, the reverse might be in keeping with what happens in vivo. Apoptotic signaling in neutrophils could, by contrast, contribute to intrinsic protection of the host's tissues. This review article, aimed preferentially but not exclusively at the cardiac surgeon, presents some new information in support of this viewpoint, which fits in with our own observations.

Key words

cardiovascular surgery - coronary bypass surgery - heart disease

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Prof. Jan Krejsek

Charles University in Prague, School of Medicine in Hradec Kralove
Department of Clinical Immunology and Allergology University Hospital

Sokolska St. 581

500 05 Hradec Kralove

Czech Republic

Fax: + 42 04 95 83 20 15

Email: krejsek@fnhk.cz