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Am J Perinatol 1997; 14(10): 605-608
DOI: 10.1055/s-2008-1040762
ORIGINAL ARTICLE

© 1997 by Thieme Medical Publishers, Inc.

Circulating Thrombomodulin Levels and Clinical Correlates in Pregnant Diabetics

Urania Magriples1 , Chaur-Dong Hsu1 , Daniel W. Chan2 , Nancy Nickless1 , Joshua A. Copel1
  • 1Departments of Obstetrics and Gynecology, Yale University, New Haven, Connecticuty
  • 2Johns Hopkins University School of Medicine, Baltimore, Maryland
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Publication Date:
04 March 2008 (online)

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ABSTRACT

The object of this study was to investigate the relationship of thrombomodulin (TM) and glycosylated hemoglobin (HbA1C) in pregnant diabetics and to determine clinical correlates. We performed a prospective cohort study of 53 patients: 25 women with insulin-dependent diabetes (group 1) and 28 with gestational diabetes (group 2). Group 1 underwent monthly determinations of HbA1C and TM. Group 2 underwent determination at 36 weeks of gestation. There was a significant difference in HbA1C between groups 1 and 2 (p = 0.0005), but there was no difference in TM. There was no correlation between TM and HbA1C. TM levels correlated positively with serum creatinine (r = 0.46, p = 0.002), proteinuria (r = 0.48, p = 0.007), and duration of diabetes (r = 0.41, p = 0.042). TM was significantly higher in diabetics of advanced White Classification (p = 0.008). With good control, TM does not appear to be elevated in a diabetic pregnancy. TM may be a marker of endothelial damage that correlates more with duration of diabetes and renal disease than with HbA1C, which reflects short-term control.

Keywords

Thrombomodulin - diabetes mellitus - glycosylated hemoglobin