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Horm Metab Res 2008; 40(2): 147-154
DOI: 10.1055/s-2008-1042430
Review

© Georg Thieme Verlag KG Stuttgart · New York

Cellular Therapies for Type 1 Diabetes

D. D. Lee 1 , 2 , E. Grossman 1 , A. S. Chong 1
  • 1Section of Transplantation, Department of Surgery, The University of Chicago, IL, USA
  • 2Department of General Surgery, Rush University Medical Center, IL, USA
Further Information

Publication History

received 01.08.2007

accepted 25.10.2007

Publication Date:
19 February 2008 (online)

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Abstract

Type 1 diabetes mellitus (T1DM) is a disease that results from the selective autoimmune destruction of insulin-producing β-cells. This disease process lends itself to cellular therapy because of the single cell nature of insulin production. Murine models have provided opportunities for the study of cellular therapies for the treatment of diabetes, including the investigation of islet transplantation, and also the possibility of stem cell therapies and islet regeneration. Studies in islet transplantation have included both allo- and xeno-transplantation and have allowed for the study of new approaches for the reversal of autoimmunity and achieving immune tolerance. Stem cells from hematopoietic sources such as bone marrow and fetal cord blood, as well as from the pancreas, intestine, liver, and spleen promise either new sources of islets or may function as stimulators of islet regeneration. This review will summarize the various cellular interventions investigated as potential treatments of T1DM.

Key words

type 1 diabetes mellitus - islet transplantation - β-cells - stem cell therapy

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Correspondence

A.S. Chong

University of Chicago

5841 South Maryland Ave

SBRI J547 [MC 5026]

Chicago

60637 IL

USA

Phone: +1/773/702 55 21

Fax: +1/773/702 55 17

Email: achong@surgery.bsd.uchicago.edu