Recent Advances in Direct Arylation via Palladium-Catalyzed Aromatic C-H Activation

Bi-Jie Li; Shang-Dong Yang; Zhang-Jie Shi

doi:10.1055/s-2008-1042907

ACCOUNT

Recent Advances in Direct Arylation via Palladium-Catalyzed Aromatic C-H Activation

Bi-Jie Li, Shang-Dong Yang, Zhang-Jie Shi*
Beijing National Laboratory of Molecular Sciences and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, P. R. of China
Fax: +86(10)62760890; e-Mail: zshi@pku.edu.cn;

Abstract

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Abstract

Highly selective arylation catalyzed by palladium and directed by the acetamino group provides an efficient and practical protocol for constructing unique biaryl scaffolds, which could be further transformed into different structural units found in a range of natural products.

1 Introduction

2 Highly Regioselective Halogenation

3 Highly Regioselective Arylation

3.1 With Arylboronic Acids

3.2 With Trialkoxyarylsilanes

3.3 With Simple Arenes

3.4 Further Transformations

4 Conclusion

Key words

C-H activation - arylation - palladium - catalysis - acetanilide

Full Text

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