One-Pot Synthesis of 6-(Pyridyl)salicylates by Formal [3+3] Cyclizations of 1,3-Bis(silyl enol ethers) with 3-Pyridyl-3-silyloxy-2-en-1-ones

Abstract

6-(Pyridyl)salicylates were regioselectively prepared by formal [3+3] cyclization of 1,3-bis(silyl enol ethers) with 3-(pyridyl)-3-silyloxy-2-en-1-ones. These reactions represent what are, to the best of our knowledge, the first [3+3] cyclizations of 1,3-bis(silyl enol ethers) with heterocyclic substrates.

Key words

cyclizations - heterocycles - regioselectivity - pyridines - silyl enol ethers

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