Long-Term Effect of Electrostimulation of the Subthalamic Nucleus in Bradykinetic-Rigid Parkinson's Disease*

J. R. Moringlane; A. O. Ceballos-Baumann; F. Alesch

doi:10.1055/s-2008-1052028

min - Minimally Invasive Neurosurgery, Inhaltsverzeichnis

Minim Invasive Neurosurg 1998; 41(3): 133-136
DOI: 10.1055/s-2008-1052028

Long-Term Effect of Electrostimulation of the Subthalamic Nucleus in Bradykinetic-Rigid Parkinson's Disease*

J. R. Moringlane¹ , A. O. Ceballos-Baumann² , F. Alesch³

¹Department of Neurosurgery, Saarland University, Homburg/Saar, Germany
²Clinic of Neurology, Technische Universität rechts der lsar, Munich, Germany
³Department of Neurosurgery, Allgemeines Krankenhaus, Vienna, Austria

* Presented in part at the Congress of the European Society for Stereotactic and Functional Neurosurgery, Milan, June 12-15, 1996.

Abstract

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Abstract

The motor effects of unilateral stimulation of the subthalamic nucleus on hypokinesia were studied in two patients 58 and 52 years old, both modified Hoehn and Yahr 2.5, at 16 and 15 months after the implantation of a quadripolar electrode (Medtronic). Motor UPDRS, time in the pegboard test, Walking time, tapping, and serial reaction times were recorded. Chronic unilateral stimulation was associated with reversible improvement of measures of reaction time and hypokinesia > 1 year after the stereotactic electrode implantation. The beneficial effect was mainly contralateral to the stimulation. However, improvement of axial functions was also observed (phonation, Walking).

Key words

Akinetic-rigid Parkinson's disease - Chronic electrostimulation - Subthalamic nucleus

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