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Neuropediatrics 1984; 15(2): 76-81
DOI: 10.1055/s-2008-1052345
© Georg Thieme Verlag KG Stuttgart · New York

Cerebellar Atrophy Following Diphenylhydantoin Intoxication

W. K. Baier1 , Ulrike  Beck1 , H.  Doose1 , H.  Klinge2 , W.  Hirsch3
  • 1University of Kiel, Neuropediatric Department, Schwanenweg 20, D-2300 Kiel, Federal Republic of Germany
  • 2University of Kiel, Neurosurgical Department, Weimarer Straße 8, D-2300 Kiel, Federal Republic of Germany
  • 3University of Kiel, Radiological Department, Arnold Heller-Straße 9, D-2300 Kiel, Federal Republic of Germany
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Publikationsdatum:
14. Mai 2008 (online)

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Abstract

Seven epileptic patients with permanent ataxic dysfunction following DPH treatment are described. The ataxia correlates with cerebellar atrophy, though the extents of clinical and structural lesions are not necessarily proportional. Cerebellar atrophy is demonstrated by CT scans, the vermal region seems to be predominantly affected. - The tentatively increased susceptibility of female patients and of patients with pre-existing brain lesions, as well as the possible consequences pertaining to the course of the epilepsy are discussed.

Key words

Epilepsy - Diphenylhydantoin - Cerebellar atrophy - Computerized tomography