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Neuropediatrics 1988; 19(2): 92-95
DOI: 10.1055/s-2008-1052408
Original articles

© Georg Thieme Verlag KG Stuttgart · New York

Tools to Differentiate Immunologic and Non-lmmunologic Myasthenia Gravis in Infancy

Marcela I. Garcia Erro1 , R. E. P. Sica1 , A. S. Losavio2 , S.  Muchnik2 , H.  Arroyo3
  • 1Sección Electroneurofisiologia Clinica, Div. Neurologia, Htal. Ramos Mejia, Urquiza 609, Bs. As., Argentina
  • 2Sección Neurofisiologia, Instituto de Investigaciones Medicas "Dr. Alfredo Lanari", Univ. Bs. As., Donato Alvarez 3150, Bs. As., Argentina
  • 3División Neurologia, Htal de Niños "Ricardo Gutierrez", Sanchez de Bustamante 1399, Bs. As., Argentina
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Publikationsdatum:
19. März 2008 (online)

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Abstract

Twelve patients between 15 months and 13 years of age with clinical and pharmacological features of myasthenia gravis were studied. Repetitive nerve stimulation did not offer valuable information; the patients demonstrated either inspecific muscular decremental response or had normal behavior. Two clear groups of patients were identified after measurements of acetylcholine receptor (AChR) antibodies and MEPP amplitude recorded in the diaphragm of mice injected with sera from those patients. The first group included patients with positive AChR antibodies titers and decreased MEPP amplitude. The second one had negative AChR antibodies titers and MEPPs with normal amplitude. These data strongly suggest immunologic and non-immunologic mechanisms for the former and later respectively.

Key words

Infantile myasthenia - Differential diagnosis