The Effect of Cortisol on the Plastic Synapses in the Developing Mouse Brain

A. Tateno; N. Koya; T. Aoki; F. Nasu

doi:10.1055/s-2008-1052410

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Neuropediatrics 1988; 19(2): 101-104
DOI: 10.1055/s-2008-1052410

Original articles

The Effect of Cortisol on the Plastic Synapses in the Developing Mouse Brain

A. Tateno¹ , N. Koya¹ , T. Aoki¹ , F. Nasu²

¹Department of Pediatrics, Ohashi Hospital, Toho University School of Medicine, Ohashi 2-16-7, Meguro-ku, Tokyo, Japan
²Department of Anatomy, Toho University School of Medicine, Oomorinishi 5-21-16, Oota-ku, Tokyo, Japan

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Publikationsdatum:
19. März 2008 (online)

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Abstract

We studied the effect of Cortisol on the plastic synapses in the hippocampal region of the developing mouse brain. Ethanolic phosphotungustic acid-stained synaptic junctions were reduced in the cortisol-treated mouse brain dosedependently and irreversibly. The steroid therapy in infancy requires circumspection.

Key words

Cortisol - Plastic synapses - Synaptic junction - Ethanolic phosphotungustic acid - Hippocampal region