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Neuropediatrics 1987; 18(1): 34-36
DOI: 10.1055/s-2008-1052431
DOI: 10.1055/s-2008-1052431
Aggregation of Bilirubin in Injectates and Incubation Media: Its Significance in Experimental Studies of CNS Toxicity
Further Information
Publication History
Publication Date:
19 March 2008 (online)
Abstract
In experimental work with bilirubin toxicity, incubates or injectates are prepared without added albumin, or with a molar excess of bilirubin over albumin. Bilirubin is liable to aggregation as free bilirubin acid under these circumstances, giving rise to variable toxicity. Stable solutions are obtained with a molar excess of albumin over bilirubin; such solutions show no toxicity, however. It is suggested that this difficulty may be circumvented by using an excess of albumin, adding a sulfonamide as a bilirubin displacer, to provoke toxicity.
Key words
Bilirubin toxicity - Bilirubin - Experimental techniques - Bilirubin aggregation