A Suspected Case of Late-Onset Sodium-Valproate-lnduced Hepatic Failure

H. van Egmond; P. Degomme; Helena de Simpel; Anne-Marie Dierick; H. Roels

doi:10.1055/s-2008-1052461

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Neuropediatrics 1987; 18(2): 96-98
DOI: 10.1055/s-2008-1052461

A Suspected Case of Late-Onset Sodium-Valproate-lnduced Hepatic Failure

H. van Egmond¹ , P. Degomme¹ , Helena de Simpel¹ , Anne-Marie Dierick² , H. Roels²

¹Department of Pediatrics, University Hospital, Gent State University, De Pintelaan 185, B-9000 Gent, Belgium
²Department of Pathology, University Hospital, Gent State University, De Pintelaan 185, B-9000 Gent, Belgium

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Publikationsdatum:
16. Mai 2008 (online)

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Abstract

A 15-year-old boy was under anti-epileptic medication (diphenylhydantoine, phenobarbital and Na valproate) for more than five years. He was admitted in cerebral coma and died after 24 hours. The histological findings suggest a valproate induced liver toxicity. This long interval between start of treatment and a possibly related hepatic failure has not been described.

Key words

Antiepileptic drugs - Sodium valproate - Chronic intoxication - Late onset