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Semin intervent Radiol 1998; 15(2): 215-222
DOI: 10.1055/s-2008-1057048
Copyright © 1998 by Thieme Medical Publishers, Inc.

Blood Pool Agents for MRA

E. Kent Yucel, Randall B. Lauffer
  • EPIX Medical Inc., Cambridge, MA
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Publication Date:
21 May 2008 (online)

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Abstract

This chapter reviews new blood pool agents and studies performed to evaluate them. The major differences between a variety of blood pool agents are identified. These agents include large gadolinium (Gd)-labeled polymers, ultrasmall superpapramagnetic particles of iron oxide (USPIO), and MS-325, a small Gd chelate that binds to serum albumin (HAS). The chapter also outlines some early phase I trials on normal human subjects.

Keywords:

Gadolinium - intravascular contrast - magnetic resonance angiography - MS = 325 - iron oxide