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Neuropediatrics 1982; 13(4): 216-218
DOI: 10.1055/s-2008-1059626
© Georg Thieme Verlag KG Stuttgart · New York

Lack of Structural Abnormalities in Lymphocytes from Heterozygotes of Juvenile Type of Generalized Ceroid-Lipofuscinosis. A Light and Electron Microscopic Study

K. -F. Bürrig1 , G.  Schwendemann1 , J.  Löhler2
  • 1Abteilung für Neuropathologie und experimentelle Hirnforschung der Psychiatrischen Universitätsklinik Hamburg
  • 2Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg
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Publikationsdatum:
19. März 2008 (online)

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Abstract

Peripheral blood lymphocytes of parents of children suffering from generalized ceroid-lipofuscinosis were entirely free of structural abnormalities; these were found exclusively in affected children. It is concluded that screening of lymphocytes is not suitable for detecting heterozygotes of juvenile type of ceroid-lipofuscinosis.

Key words

Ceroid-lipofuscinosis - Lymphocyte inclusions - Heterozygotes