RSS-Feed abonnieren
DOI: 10.1055/s-2008-1061499
Plasma Exchange in a Case of Severe Factor X Deficiency in Pregnancy: Critical Review of the Literature
Publikationsverlauf
Publikationsdatum:
29. Februar 2008 (online)
![](https://www.thieme-connect.de/media/ajp/200803/lookinside/thumbnails/10.1055-s-2008-1061499-1.jpg)
ABSTRACT
Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.
KEYWORDS
Pregnancy - factor X deficiency - plasma exchange - prothrombin complex concentrates
REFERENCES
- 1 Uprichard J, Perry D J. Factor X deficiency. Blood Rev. 2002; 16 97-110
- 2 Konje J C, Murphy P, de Chazal R, Davidson A, Taylor D. Severe factor X deficiency and successful pregnancy. Br J Obstet Gynaecol. 1994; 101 910-911
- 3 Larrain C. Congenital blood coagulation factor X deficiency. Successful result of the use of prothrombin concentrated complex in the control of cesarean section hemorrhage in 2 pregnancies. Rev Med Chil. 1994; 122 1178-1183
- 4 Kumar M, Mehta P. Congenital coagulopathies and pregnancy: report of four pregnancies in a factor X deficient woman. Am J Hematol. 1994; 46 241-244
- 5 Bofill J A, Young R A, Perry K G. Successful pregnancy in a woman with severe factor X deficiency. Obstet Gynecol. 1996; 88 723
- 6 Rezig K, Diar N, Benabidallah D, Audibert J. Déficit en facteur X et grossesse. Ann Fr Anesth Reanim. 2002; 21 521-524
- 7 Romagnolo C, Burati S, Ciaffoni S et al.. Severe factor X deficiency in pregnancy: case report and review of literature. Haemophilia. 2004; 10 665-668
-
8 Seligsohn U, Zivelin A, Inbal A.
Inherited deficiencies of coagulation factors II, V, VII, X, XI and XIII and combined deficiencies of factors V and VII and the vitamin K dependent factors . In: Lichtman MA, Beutler E, Kipps JT, Seligsohn U, Kaushansky K, Prchal JT Williams Hematology. 7th ed. New York; McGraw-Hill 1996: 1887-1928 -
9 Edmunds Jr L H.
Hemostatic problems in surgical patients . In: Colman RW, Marder VJ, Clowes AW, George JN, Goldhaber SZ Hemostasis and Thrombosis. 5th ed. Philadelphia; Lippincott Williams & Wilkins 2006: 1106-1118 - 10 Spero J A. Plasma exchange for coagulopathy and/or coagulation inhibitors. J Clin Apher. 1985; 2 278-281
- 11 Beardell F V, Varma M, Martinez J. Normalization of plasma factor X levels in amyloidosis after plasma exchange. Am J Hematol. 1997; 54 68-71
-
12 Weinstein R.
Plasma exchange . In: McLeod B, Price T, Weinstein R Apheresis: Principle and Practice. 2nd ed. Bethesda, MD; American Association of Blood Banks (AABB) 2003: 313 - 13 Girolami A, Lazzarini M, Scarpa R, Brunetti A. Further studies on the abnormal factor X (factor X Friuli) coagulation disorder: a report of another family. Blood. 1971; 37 534-541
Giuseppe ChiossiM.D.
Department of Obstetrics and Gynecology, Allegheny General Hospital
7th Floor South Tower, 320 East North Avenue, Pittsburgh, PA 15212