Am J Perinatol 2008; 25(4): 233-237
DOI: 10.1055/s-2008-1066875
© Thieme Medical Publishers

The Effect of Body Mass Index on Therapeutic Response to Bacterial Vaginosis in Pregnancy

Joan M. Mastrobattista1 , Mark A. Klebanoff2 , J. Christopher Carey3 , John C. Hauth4 , Cora A. MacPherson5 , J. Ernest6 , Margaret Cotroneo7 , Kenneth J. Leveno8 , Ronald Wapner9 , Michael Varner10 , Jay D. Iams11 , Atef Moawad12 , Baha M. Sibai13 , Menachem Miodovnik14 , Mitchell Dombrowski15 , Mary J. O'Sullivan16 , J. Peter VanDorsten17 , Oded Langer18 , for the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Texas Medical School at Houston, Houston, Texas
  • 2Division of Epidemiology, Statistics & Prevention Research National Institute of Child Health and Human Development, Bethesda, Maryland
  • 3University of Colorado School of Medicine, Denver, Colorado
  • 4Department of Obstetrics and Gynecology, University of Alabama, Birmingham, Alabama
  • 5Department of Epidemiology and Biostatistics, The George Washington University Biostatistics Center, Rockville, Maryland
  • 6Department of Obstetrics and Gynecology, Wake Forest University, Winston-Salem, North Carolina
  • 7Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Women's Hospital, Pittsburgh, Pennsylvania
  • 8Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
  • 9Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Columbia Medical University, New York, New York
  • 10Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah
  • 11Department of Obstetrics and Gynecology, Ohio State University, Columbus, Ohio
  • 12Department of Obstetrics and Gynecology, University of Chicago Medical Center, Chicago, Illinois
  • 13Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio
  • 14Department of Obstetrics and Gynecology, Washington Hospital Center, Washington, D.C.
  • 15Department of Obstetrics and Gynecology, St. John Hospital, Detroit, Michigan
  • 16Department of Obstetrics and Gynecology, University of Miami, Division of Research, Miami, Florida
  • 17Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina
  • 18Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, New York, New York
Further Information

Publication History

Publication Date:
18 March 2008 (online)

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ABSTRACT

Our objective was to determine the effect of body mass index (BMI) on response to bacterial vaginosis (BV) treatment. A secondary analysis was conducted of two multicenter trials of therapy for BV and Trichomonas vaginalis. Gravida were screened for BV between 8 and 22 weeks and randomized between 16 and 23 weeks to metronidazole or placebo. Of 1497 gravida with asymptomatic BV and preconceptional BMI, 738 were randomized to metronidazole; BMI was divided into categories: < 25, 25 to 29.9, and ≥ 30. Rates of BV persistence at follow-up were compared using the Mantel-Haenszel chi square. Multiple logistic regression was used to evaluate the effect of BMI on BV persistence at follow-up, adjusting for potential confounders. No association was identified between BMI and BV rate at follow-up (p = 0.21). BMI was associated with maternal age, smoking, marital status, and black race. Compared with women with BMI of < 25, adjusted odds ratio (OR) of BV at follow-up were BMI 25 to 29.9: OR, 0.66, 95% CI 0.43 to 1.02; BMI ≥ 30: OR, 0.83, 95% CI 0.54 to 1.26. We concluded that the persistence of BV after treatment was not related to BMI.

KEYWORDS

Body mass index - bacterial vaginosis - pregnancy - treatment

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Joan MastrobattistaM.D. 

Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Texas Health Science Center at Houston

6431 Fannin St., Room 3.274, Houston, TX 77030