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Synthesis 2008(13): 2039-2044  
DOI: 10.1055/s-2008-1067108
PAPER
© Georg Thieme Verlag Stuttgart · New York

First Synthesis of 3,6′- and 3,7′-Biquinoline Derivatives

Sidonie Broch, Fabrice Anizon, Pascale Moreau*
Laboratoire de Synthèse Et Etude de Systèmes d’Intérêt Biologique-UMR CNRS 6504, Université Blaise Pascal, 24 Avenue des Landais, 63177 Aubière Cedex, France
Fax: +33(4)73407717; e-Mail: Pascale.MOREAU@univ-bpclermont.fr;
Further Information

Publication History

Received 12 February 2008
Publication Date:
21 May 2008 (online)

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Abstract

The preparation of new 3,6′- and 3,7′-biquinoline derivatives was achieved by microwave-assisted Suzuki cross-coupling between N-protected 6- or 7-bromoquinolin-2(1H)-ones and quinolin-3-ylboronic acid. Moreover, a new synthesis of 7-bromoquinolin-2(1H)-one leading solely to the 7-substituted isomer was carried out.

Keywords

quinoline - quinolinone - 6-bromoquinolin-2(1H)-one - 7-bromoquinolin-2(1H)-one - Suzuki cross-coupling

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