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Synthesis 2008(13): 2077-2082
DOI: 10.1055/s-2008-1067112
DOI: 10.1055/s-2008-1067112
PAPER
© Georg Thieme Verlag Stuttgart · New York
One-Pot Multicomponent Synthesis of N-Substituted Tryptophan-Derived Diketopiperazines
Further Information
Received
31 March 2008
Publication Date:
21 May 2008 (online)
Publication History
Publication Date:
21 May 2008 (online)
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Abstract
A simple, rapid, one-pot multicomponent synthesis of tryptophan-derived diketopiperazines with variable side chains is presented. Microwave radiation gives comparable yields, but allows a significant decrease in reaction times.
Key words
multicomponent reactions - heterocycles - diketopiperazines - dioxopiperazines - tryptophan - indole alkaloids
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