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DOI: 10.1055/s-2008-1067126
A Novel and Efficient Synthesis of 1-Hydroxyquinazolin-4-ones via Tin(II) Chloride Induced Cyclization of 2-Nitrobenzamides and Ketones
Publication History
Publication Date:
11 June 2008 (online)
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Abstract
A mild, efficient and novel synthesis of 2,3-dihydro-1-hydroxyquinazolin-4(1H)-ones via cyclization of 2-nitrobenzamides and ketones induced by tin(II) chloride dihydrate is described. This new method has the advantages of accessible starting materials, convenient manipulation, short reaction times, and high yields.
Key words
tin(II) chloride dihydrate - 1-hydroxyquinazolin-4-one - 2-nitrobenzamide - ketone
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References
Crystallographic data for the structures of 3a (CCDC-682915), 5b (CCDC-682916), 7e (CCDC-682917), and 9a (CCDC-682918) have been deposited at the Cambridge Crystallographic Data Centre. Copies of available material can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44 (1223)336033; email: deposit@ccdc.cam.ac.uk].