A Practical Synthesis of the C1-C9 Fragment of Dictyostatin

Abstract

A stereoselective synthesis of the C1-C9 fragment of (-)-dictyostatin has been achieved by use of a titanium(IV) chloride mediated chelation-controlled Mukaiyama aldol reaction and two modified Horner-Wadsworth-Emmons olefinations (Roush-Masamune and Still-Gennari).

Key words

antitumor agents - stereoselective synthesis - aldol reactions - titanium - olefination

References

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Novartis AG, Annual Report, file no. 1-15024, Form 20-F, Jan 28, 2005, p 42.