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Synthesis 2008(15): 2347-2352
DOI: 10.1055/s-2008-1067160
DOI: 10.1055/s-2008-1067160
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Pd(OAc)2-Catalyzed Aminocarbonylation of Aryl Iodides with Aromatic or Aliphatic Amines in Water
Further Information
Publication History
Received
31 March 2008
Publication Date:
08 July 2008 (online)
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Abstract
An efficient ligand-free protocol has been developed for the amincocarbonylation of aryl iodides with aromatic/aliphatic amines using palladium(II) acetate as a catalyst in water under milder operating conditions. The system tolerated a wide variety of hindered and functionalized aryl iodides/amines and afforded the desired amides in excellent yields at low catalyst concentration.
Key words
carbonylation - aryl iodides - amines - amides - palladium