2-Allylphenols undergo smooth cross coupling with ketones under
mild conditions to produce spirocyclic oxepins in good yields with
high chemoselectivity, whereas aromatic aldehydes provide benzoxepins
with moderate stereoselectivity. The use of aluminum(III) chloride
makes this method simple, convenient, and cost effective.
Prins cyclization - 2-allylphenols - carbonyl
compounds - benzoxepins
