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DOI: 10.1055/s-2008-1067233
An Easy and Efficient One-Step Procedure for the Preparation of Alkyl and Aryl Alkylcarbamates from S-Methyl N-Alkylthiocarbamates
Publication History
Publication Date:
22 August 2008 (online)
Abstract
A general, one-step procedure for the synthesis of alkyl and aryl alkylcarbamates, by the direct reaction of S-methyl N-alkylthiocarbamates with alcohols or phenols in toluene at reflux in the presence of triethylamine, is reported. All the target products were obtained in high yield (15 examples, average yield 94%) and very high purity (>99.2%). The recovery of a co-product of industrial interest, methanethiol, in an amount of one mole for each mole of thiocarbamate, with complete exploitation of the reagent, should also be noted.
Key words
carbamates - thiocarbamates - S,S-dimethyl dithiocarbonate - green chemistry
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Professor Emeritus, University of Turin (Italy).
10For details, see IT patent application pending: Carvoli, G.; Degani, I.; Pallucca, E.; Fochi, R.; Gazzetto, S.; Artuso, E.; Lazzaroni, M.; Cadamuro, S. Oxon Italia S.p.A. Italy, patent request No. MI 2005 001284, 2005.
17Oxon Italia S.p.A., 20016 Pero (Milano), Italy