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Synthesis 2008(18): 2929-2932  
DOI: 10.1055/s-2008-1067246
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Bis(aminofuryl)bicinchoninic Amides by a One-Pot Three-Component Reaction of Isocyanides, Acetylenic Esters, and Bicinchoninic Acid

Abdolali Alizadeh*a, Qasem Oskueyana, Sadegh Rostamniaa, Abbass Ghanbari-Niakib, Ali Rreza Mohebbic
a Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran 18716, Iran
b Department of Physical Education & Sports Science, Tarbiat Modares University, P.O. Box 14115-175, Tehran 18716, Iran
c Otto-Diels-Institut für Organische Chemie, Christian-Albrechts University of Kiel, 24098 Kiel, Germany
Fax: +98(21)88006544; e-Mail: abdol_alizad@yahoo.com; e-Mail: aalizadeh@modares.ac.ir;
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Received 9 May 2008
Publikationsdatum:
22. August 2008 (online)

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Abstract

A simple synthesis of dialkyl 2-(alkylamino)-5-[alkyl({2-[4-({alkyl[5-(alkylamino)-3,4-bis(alkoxycarbonyl)-2-furyl]amino}carbonyl)-2-quinolyl]-4-quinolyl}carbonyl)amino]-3,4-furandicarboxylate derivatives is described. This involves reaction of isocyanides, dialkyl acetylenedicarboxylates, and bicinchoninic acid (BCA) in MeCN-THF at 25 ˚C for 36 hours.

Key words

dialkyl acetylenedicarboxylate - isocyanide - bicinchoninic acid - multicomponent reaction - bicinchoninic amide