Download PDF
Neuropediatrics 1991; 22(4): 184-189
DOI: 10.1055/s-2008-1071438
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Contribution of Magnetic Resonance Imaging in the Evaluation of Microcephaly*

M.  Steinlin , M.  Zürrer , E.  Martin , Ch.  Boesch , R. H. Largo , E.  Boltshauser
  • Children's University Hospital, CH-8032 Zürich, Switzerland
* Supported by Swiss National Foundation grant No.: 3.917-0.88 and 3824-0.87.
Further Information

Publication History

Publication Date:
19 March 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Magnetic resonance imaging (MRI) was performed in 33 children using a 2,35 T MR system. The intention was to determine the various types of morphological abnormalities seen in primary microcephaly and the frequency with which they occur. MRI findings were typical for cytomegalovirus infection in six patients. Cerebral malformations were found in 14 cases and patchy white matter lesions in both hemispheres in two subjects. MRI appeared to be abnormal in eight of the remaining 11 children. However, we were unable to provide an exact interpretation of the findings. All the children with MRI abnormalities with the exception of two were neurodevelopmentally deviant. Thus, MRI revealed abnormalities in the majority of infants with primary microcephaly and neurodevelopmental disturbances. It appears to be more sensitive than cranial ultrasound and computed tomography.

Abbreviations

MRI: magnetic resonance imaging, CT: computed tomography, CMV: Cytolomegalovirus, T: Tesla

Key words

Microcephaly - Magnetic resonance imaging - Malformations - Myelination disorders - Cytomegalovirus infection