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Neuropediatrics 1993; 24(4): 204-207
DOI: 10.1055/s-2008-1071540
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Clinicopathological Study of Pontosubicular Necrosis

T.  Mito , A.  Kamei , S.  Takashima , L. E. Becker
  • 1Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Tokyo, Japan; Department of
    Pathology, University of Toronto and The Hospital for Sick Children, Toronto, Canada
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Publication History

Publication Date:
19 March 2008 (online)

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Abstract

Clinicopathological features were examined in 65 neonates and 8 stillborn infants with pontosubicular necrosis (PSN) compared to 57 neonates and 19 stillborn infants without PSN. Twelve out of 65 neonates with PSN had congenital heart disease and 3 out of 65 neonates showed persistent fetal circulation. On neuropathological examination, the frequency of neonates with PSN who also showed karyorrhectic/eosinophilic neurons in other regions of the brain stem, basal ganglia and thalamus was higher than in controls. The results of this study suggest that acute ischemia is an important underlying pathogenetic factor and PSN occurs in the prenatal as well as postnatal period.

Key words

Pontosubicular necrosis - Neonate - Fetus - Ischemia - Total asphyxia