Clinical Features of Kleine-Levin Syndrome with Localized Encephalitis

F. Fenzi; A. Simonati; F. Crosato; L. Ghersini; N. Rizzuto

doi:10.1055/s-2008-1071559

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Neuropediatrics 1993; 24(5): 292-295
DOI: 10.1055/s-2008-1071559

Short communication

Clinical Features of Kleine-Levin Syndrome with Localized Encephalitis

F. Fenzi¹ , A. Simonati¹ , F. Crosato² , L. Ghersini² , N. Rizzuto¹

¹Istituto di Neurologia, Universita di Verona, Italy
²Unita Operativa di Neuropsichiatria Infantile, Ospedale S. Chiara, Trento, Italy

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Publication History

Publication Date:
19 March 2008 (online)

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Abstract

We report the clinico-pathological findings regarding a 9 year-old girl with some clinical features of Kleine-Levin syndrome who died suddenly as a result of pulmonary embolism in the course of femoro-iliac thrombophlebitis. Neuropathological examination provided evidence of perivascular inflammatory infiltrates and microglial proliferation of nodular type located in the diencephalon and midbrain. These findings suggest that a localized encephalitis may be the underlying condition in Kleine-Levin syndrome.

Key words

Kleine-Levin syndrome - Localized encephalitis - Diencephalic and midbrain lesions