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Neuropediatrics 1993; 24(6): 339-340
DOI: 10.1055/s-2008-1071568
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© Georg Thieme Verlag KG Stuttgart · New York

Lamotrigine in Rett Syndrome

P.  Uldall1 , F. J. Hansen2 , B.  Tonnby3
  • 1Child Department, Dianalund Epilepsy Hospital, Denmark
  • 2Department of Pediatrics, Rigshospitalet, Copenhagen, Denmark
  • 3Habilitation Unit, Halmstad, Sweden
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Publication History

Publication Date:
19 March 2008 (online)

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Abstract

An elevated CSF glutamate level has recently been reported in Rett syndrome. Because the anticonvulsant effect of Lamotrigine is probably due to inhibition of glutamate release, this drug was given as an add-on drug to 4 girls with Rett syndrome. All patients responded with a seizure reduction of 50% or more and an improved well-being. A controlled study at the early stages of the syndrome could be interesting.

Abbreviations

RS, Rett syndrome
LTG, Lamotrigine
VPA, valproic acid
PB, phenobarbital
CLB, clobazam
CBZ, carbamazepine
ESM, ethosuximide
VGT, vigabatrin
OXC, oxcarbazepin
GTCS, generalized tonic-clonic seizures

Key words

Rett syndrome - Seizures - Lamotrigine