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Neuropediatrics 1994; 25(1): 4-7
DOI: 10.1055/s-2008-1071573
Review article

© Georg Thieme Verlag KG Stuttgart · New York

Inherited or Acquired Disorders of Blood Coagulation in Children with Neurovascular Complications

U.  Göbel
  • Department of Pediatric Hematology and Oncology, Childrens Hospital, Heinrich-Heine-University, Düsseldorf, Germany
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Publikationsdatum:
15. Mai 2008 (online)

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Abstract

Congenital or acquired disorders of hemostasis can cause thrombotic events in adults as well as in children. Recently, acute neurologic complications such as hemiparesis or transitory ischemic attacks (TIA) have been reported in patients with different disorders of hemostasis. In addition, the interaction between anionic antiphospholipid antibodies and inhibition of the coagulation have to be considered for these clinical manifestation. This review aims at putting the clinical and experimental data which are currently available for children into perspective.

Abbreviations

APA: antiphospholipid antibodies
AT III : antithrombin III
CLA: cardiolipin antibody
Ig: immunoglobulin
LA: lupus anticoagulant
PA: plasminogen activator inhibitor
PC: protein C
PCa: activated protein C
PS: protein S
PTT: partial thromboplastin time

Key words

Stroke - Coagulation - Antiphospholipid antibodies - Neurovascular disorders