Conversion of N-Acyl Amino Acids into Imides via Oxidative Decarboxylation Induced by Ag⁺/Cu²⁺/S₂O₈ ^2- in Water

Abstract

N-Acyl amino acids can be converted by oxidative decarboxylation induced by Ag⁺/Cu²⁺/S₂O₈ ^2- at room temperature in water into imides in 24-89% yields. Both N-benzoylvaline and N-benzoylleucine gave N-formylbenzamide, which possibly results from oxidative cleavage of an enamide intermediate.

oxidative decarboxylation - silver - copper - imide - amino acid

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We thank a reviewer for suggesting this explanation.

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