Abstract
Pyridoxine-dependent seizures are a disorder of GABA metabolism probably due to a
defective binding of pyridoxal phosphate coenzyme (PALP) with glutamate decarboxylase
(GAD), the rate-limiting enzyme in GABA synthesis. The resulting GABA deficiency causes
severe epilepsy in infancy. We report on a boy with seizures starting soon after birth,
and only controlled by pyridoxine at pharmacological dosages. After two months without
seizures, a CT scan showed hypodense white matter in frontal and occipital lobes suggestive
of a retarded or defective myelination. We are not aware of other descriptions of
such morphological abnormalities in a patient with this disorder.
Abbreviations
CSF: Cerebrospinal fluid
CNS: Central nervous system
CT: Computed tomography
EEG: Electroencephalogram
GABA: Gama-aminobutyric acid
GAD: Glutamate decarboxylase
HPLC: High performance liquid chromatography
PALP: Pyridoxal phosphate
PDS: Pyridoxine-dependent seizures
DOB: Date of birth
Key words
Pyridoxine-dependent seizures - GABA metabolism - CNS dysmyelination
