Planta Med 2008; 74(7): 760-763
DOI: 10.1055/s-2008-1074523
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Constituents from Hoya parasitica and their Cell Growth Inhibitory Activity

Samir Kumar Sadhu1 , 2 , Amina Khatun2 , Takashi Ohtsuki1 , Masami Ishibashi1
  • 1Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
  • 2Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh
Further Information

Publication History

Received: July 24, 2007 Revised: March 10, 2008

Accepted: March 10, 2008

Publication Date:
29 April 2008 (online)

Abstract

An androstanoid, hoyasterone (1), a sesquiterpene, 15-bulnesolic acid (2), and a phenolic compound, 1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropan-2-ol (3), together with a known triterpene, dihydrocanaric acid, were isolated from Hoya parasitica. Structures were elucidated by 1 D and 2 D NMR and mass spectroscopic analysis. Among the isolated compounds, only dihydrocanaric acid exhibited growth inhibitory activity against both HeLa and SW480 cells.

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Prof. Dr. Masami Ishibashi

Laboratory of Natural Products Chemistry

Graduate School of Pharmaceutical Sciences

Chiba University

1-33 Yayoi-cho

Inage-ku

Chiba 263-8522

Japan

Phone: +81-43-290-2913

Fax: +81-43-290-2913

Email: mish@p.chiba-u.ac.jp