Cytotoxicity of Prenylated Xanthones and Other Constituents from the Wood of Garcinia merguensis
Anake Kijjoa1, 2
, Maria Jose Gonzalez3, 4
, Madalena M. Pinto3, 4
, Maria São José Nascimento3, 5
, Nair Campos2
, Ing-On Mondranondra6
, Artur M.S. Silva7
, Graham Eaton8
, Werner Herz9
1ICBAS – Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal
2Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Porto, Portugal
3Centro de Estudo de Química Orgânica, Fitoquímica e Farmacologia, Universidade do Porto, Porto, Portugal
4Serviço de Química Orgânica, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
5Serviço de Microbiologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
6Department of Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
7Departamento de Química, Universidade de Aveiro, Aveiro, Portugal
8Department of Chemistry, University of Leicester, Leicester, England
9Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, Florida, USA
Further Information
Publication History
Received: January 17, 2008
Revised: March 26, 2008
One new prenylated xanthone 5-farnesyltoxyloxanthone B (4), three known xanthones α-mangostin (1), rubraxanthone (2) and isocowanol (3) as well as (2E,6E,10E)-4β-hydroxy-3-methyl-5β-(3,7,11,15-tetramethylhexadeca-2,6,10-tetraenyl)-cyclohex-2-en-1-one (5) and 3,3′,4-O-trimethylellagic acid were isolated from the wood of Garcinia merguensis Wight. The cytotoxic activities of compounds 1 – 5 were evaluated against the MCF-7, MDA-MB-231, NCI-H-460 and SF-268 cell lines with rubraxanthone 2 and 5 exhibiting the highest activity at 9.0 and 12.1 μM, respectively, against MCF-7 cells.
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