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Planta Med 1980; 38(2): 138-143
DOI: 10.1055/s-2008-1074849
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Effects of O-Methylflavinantine on the Response to Coaxial Stimulation of Guinea-Pig Ileum

B. K. Noamesi1 , E. A. Gyang2
  • 1Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria.
  • 2Department of Pharmacology, Faculty of Pharmacy, University of Science and Technology, Kumasi, Ghana.
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Publikationsdatum:
29. April 2008 (online)

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Abstract

O-methylflavmantine, an alkaloid with a morphinan structure from the plant Rhigiocarya racemifera, has been shown to depress the response of the isolated guinea-pig ileum to coaxial electrical stimulation. The depressant effect was dose dependent and the dose-response effect was more reproducible with the alkaloid than with morphine. The alkaloid showed very little tendency towards the development of tachyphylaxis and its depressant effect was not antagonised by nalorphine.

Key Word Index

Rhigiocarya racemifera - Menispermaceae - O-Methylflavinantine - Ileum - Electrical stimulation - Smooth Muscle Twitches.