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Planta Med 1980; 38(4): 366-376
DOI: 10.1055/s-2008-1074892
Research Articles

© Georg Thieme Verlag Stuttgart · New York

In vitro- und in vivo-Metabolismus von 14C-Didrovaltrat

In vitro- and in vivo-Metabolism of 14C-DidrovaltrateH. Wagner, K. Jurcic
  • Institut für pharmazeutische Arzneimittellehre der Universität München, Bundesrepublik Deutschland
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Publication Date:
29 April 2008 (online)

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Abstract

Autoradiographic and chemical investigations of different organs of mice after p. o., i. v. and intraduodenal administration of 14C-didrovaltrat, showed that it is resorbed to a small extent in the unchanged form. The main part of the incorporated radioactivity however is found as a polymeric degradation product. The fast degradation and metabolism were confirmed by in vitro incubation of 14C-didrovaltrat with plasma and liver homogenates.

Key Word Index

Valeriana walichii DC - Valerianaceae - 14C-Didrovaltrate - Valepotriate - in vitro- and in vivo metabolism in mice.