Autoradiographic and chemical investigations of different organs of mice after p.
o., i. v. and intraduodenal administration of 14C-didrovaltrat, showed that it is resorbed to a small extent in the unchanged form.
The main part of the incorporated radioactivity however is found as a polymeric degradation
product. The fast degradation and metabolism were confirmed by in vitro incubation
of 14C-didrovaltrat with plasma and liver homogenates.
Valeriana walichii DC - Valerianaceae -
14C-Didrovaltrate - Valepotriate - in vitro- and in vivo metabolism in mice.
