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Planta Med 1980; 40(12): 366-372
DOI: 10.1055/s-2008-1074987
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Pharmacological Actions of Saikosaponins isolated from Bupleurum falcatum

1. Effects of Saikosaponins on Liver FunctionHiroko Abe1 , Machiko Sakaguchi1 , Masayo Yamada1 , Shigeru Arichi1 , Shizuo Odashima2
  • 1The Research Institute of Oriental Medicine, Kinki University, Sayama, Minamikawachi-gun, Osaka, Japan
  • 2Department of Pathology, Kanazawa Medical University Uchinada, Kahoku-gun, Ishikawa, Japan
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29. April 2008 (online)

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Abstract

The changes in rat hepatocytes that occur after a 4 days period of treatment with various kinds of saikosaponins were studied.

The administration of saikosaponin a or d produced a marked decrease of microsomal enzyme activities, glucose-6-phosphatase and NADPH-cytochrome c reductase, and a significant increase of 5'-nucleotidase activity, whereas saikosaponin b1, b2 and c did not cause any change in enzyme activities.

In the rats pretreated with saikosaponin, especially saikosaponin a or d, the remarkable inhibition of D-galactosamine induced hepatic injury was observed.

Key Word Index

Bupleurum falcatum L - Saikosaponin - NADPH-cytochrome c reductase - 5'-Nucieotidase - P450 - D-Galactosamine.