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Synlett 2008(17): 2571-2578
DOI: 10.1055/s-2008-1078275
DOI: 10.1055/s-2008-1078275
ACCOUNT
© Georg Thieme Verlag
Stuttgart ˙ New York
Recent Advances in the Synthesis of Pyridines by Transition-Metal-Catalyzed [2+2+2] Cycloaddition
Weitere Informationen
Received
15 April 2008
Publikationsdatum:
21. August 2008 (online)
Publikationsverlauf
Publikationsdatum:
21. August 2008 (online)
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Abstract
Pyridines can be efficiently synthesized by the transition-metal-catalyzed [2+2+2] cycloaddition reactions between two alkynes and one nitrile. In this account, we present the state of the art in this area with particular emphasis on the metal catalyst utilized in the reaction.
1 Introduction
2 Cobalt-Catalyzed [2+2+2] Cycloadditions
3 Rhodium-Catalyzed [2+2+2] Cycloadditions
4 Ruthenium-Catalyzed [2+2+2] Cycloadditions
5 Nickel-Catalyzed [2+2+2] Cycloadditions
6 Conclusions
Key words
alkynes - cycloadditions - transition-metal catalysis - nitriles - pyridines
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In the cobalt-catalyzed reaction involving 2-ethynyl-pyridine, benzene derivatives resulting from cyclotrimerization were the major products observed.