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Synthesis 2008(14): 2283-2287  
DOI: 10.1055/s-2008-1078451
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Optically Active Amines by Enzyme-Catalyzed Kinetic Resolution

Klaus Ditrich*
GVF - Fine Chemicals & Biocatalysis Research, BASF SE, Carl-Bosch-Str. 38, 67056 Ludwigshafen, Germany
Fax: +49(621)6020440; e-Mail: klaus.ditrich@basf.com;
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Publication History

Received 11 April 2008
Publication Date:
11 June 2008 (online)

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Abstract

Chiral amines are resolved by an enzyme-catalyzed kinetic resolution. Key steps are the selective acylation of one enan­tiomer with isopropyl methoxyacetate, separation of the resulting amide from the unreacted antipode, and finally amide hydrolysis. The process proceeds with excellent selectivity and is highly flexible with regard to substrates.

Key words

amines -  enzymes -  enantiomeric  resolution - kinetic resolution

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